Drug interactions
Avapritinib + Levetiracetam
Severity: Moderate
Avapritinib and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and levetiracetam can add sedation and mood or behavioral effects. The combination may worsen drowsiness and cognitive impairment.
What this interaction means in plain words
Avapritinib and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS effects; no pharmacokinetic interaction is established.
What to do
Monitor for cognitive changes and sedation, and counsel on driving. Avapritinib dose reduction or interruption may be needed if CNS effects become significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Levetiracetam?
MediHelp rates the interaction as moderate. Avapritinib and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and levetiracetam can add sedation and mood or behavioral effects. The combination may worsen drowsiness and cognitive impairment.
How serious is the interaction between Avapritinib and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive changes and sedation, and counsel on driving. Avapritinib dose reduction or interruption may be needed if CNS effects become significant.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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