Drug interactions
Avapritinib + Loxapine
Severity: Moderate
Avapritinib and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive adverse effects including memory impairment, confusion and sleepiness. Loxapine adds sedation and may worsen cognitive impairment.
What this interaction means in plain words
Avapritinib and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and cognitive effects; no pharmacokinetic mechanism established.
What to do
Monitor for sedation and cognitive changes, and reduce the avapritinib dose or interrupt it if cognitive adverse reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Loxapine?
MediHelp rates the interaction as moderate. Avapritinib and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive adverse effects including memory impairment, confusion and sleepiness. Loxapine adds sedation and may worsen cognitive impairment.
How serious is the interaction between Avapritinib and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes, and reduce the avapritinib dose or interrupt it if cognitive adverse reactions occur.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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