Drug interactions
Avapritinib + Metaxalone
Severity: Moderate
Avapritinib and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and metaxalone adds to CNS depression. This may worsen confusion, memory problems and drowsiness.
What this interaction means in plain words
Avapritinib and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS effects; avapritinib has its own neurocognitive toxicity.
What to do
Monitor cognition and alertness, and counsel on driving risks. Reduce or stop metaxalone if cognitive effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Metaxalone?
MediHelp rates the interaction as moderate. Avapritinib and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and metaxalone adds to CNS depression. This may worsen confusion, memory problems and drowsiness.
How serious is the interaction between Avapritinib and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and alertness, and counsel on driving risks. Reduce or stop metaxalone if cognitive effects emerge.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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