Drug interactions
Avapritinib + Nicardipine
Severity: Moderate
Avapritinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly raise avapritinib levels via CYP3A4 inhibition, potentially increasing adverse effects such as cognitive effects, bleeding and edema. Strong and moderate inhibitors are the main concern; nicardipine is weaker.
What this interaction means in plain words
Avapritinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 by nicardipine reduces avapritinib clearance.
What to do
Monitor for avapritinib toxicity including cognitive changes and intracranial bleeding signs. Reduce the avapritinib dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Nicardipine?
MediHelp rates the interaction as moderate. Avapritinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may modestly raise avapritinib levels via CYP3A4 inhibition, potentially increasing adverse effects such as cognitive effects, bleeding and edema. Strong and moderate inhibitors are the main concern; nicardipine is weaker.
How serious is the interaction between Avapritinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for avapritinib toxicity including cognitive changes and intracranial bleeding signs. Reduce the avapritinib dose if adverse effects emerge.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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