Drug interactions
Avapritinib + Orphenadrin
Severity: Moderate
Avapritinib and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause sedation, cognitive effects and memory impairment, which may add to orphenadrine's CNS and anticholinergic effects. A pharmacokinetic interaction via CYP3A4 is not well established for orphenadrine.
What this interaction means in plain words
Avapritinib and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and anticholinergic effects; CYP3A4 influence is unproven.
What to do
Monitor for sedation, confusion and cognitive changes, and reduce the orphenadrine dose if they develop. Counsel patients about driving and hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Orphenadrin?
MediHelp rates the interaction as moderate. Avapritinib and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause sedation, cognitive effects and memory impairment, which may add to orphenadrine's CNS and anticholinergic effects. A pharmacokinetic interaction via CYP3A4 is not well established for orphenadrine.
How serious is the interaction between Avapritinib and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and cognitive changes, and reduce the orphenadrine dose if they develop. Counsel patients about driving and hazardous tasks.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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