Drug interactions
Avapritinib + Primaquine
Severity: Moderate
Avapritinib and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is a CYP3A4 substrate, and a weak CYP3A4 inhibitor such as primaquine could modestly raise exposure. Higher avapritinib exposure may increase adverse effects such as cognitive effects, intracranial bleeding or edema.
What this interaction means in plain words
Avapritinib and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Primaquine belongs to Anti Parasitic.
Why it happens
Possible weak inhibition of CYP3A4-mediated avapritinib metabolism.
What to do
Monitor for avapritinib toxicity, including cognitive changes and bleeding, and reduce the dose if adverse effects emerge. Consider an alternative antimalarial if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Primaquine?
MediHelp rates the interaction as moderate. Avapritinib and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib is a CYP3A4 substrate, and a weak CYP3A4 inhibitor such as primaquine could modestly raise exposure. Higher avapritinib exposure may increase adverse effects such as cognitive effects, intracranial bleeding or edema.
How serious is the interaction between Avapritinib and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for avapritinib toxicity, including cognitive changes and bleeding, and reduce the dose if adverse effects emerge. Consider an alternative antimalarial if appropriate.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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