Drug interactions
Avapritinib + Ramelteon
Severity: Moderate
Avapritinib and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, which may add to the sedation of ramelteon. This may reduce alertness and impair daily function.
What this interaction means in plain words
Avapritinib and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Ramelteon belongs to Central Nervous System.
Why it happens
Additive CNS effects; the interaction is predicted pharmacodynamically and not well characterized.
What to do
Monitor for sedation and cognitive changes, and counsel patients about driving and machinery use. Reduce or stop ramelteon if cognitive impairment emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Ramelteon?
MediHelp rates the interaction as moderate. Avapritinib and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, which may add to the sedation of ramelteon. This may reduce alertness and impair daily function.
How serious is the interaction between Avapritinib and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes, and counsel patients about driving and machinery use. Reduce or stop ramelteon if cognitive impairment emerges.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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