Drug interactions
Avapritinib + Rifampicin
Severity: Major
Avapritinib and Rifampicin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin strongly induces CYP3A4 and greatly reduces avapritinib exposure, likely causing loss of efficacy.
What this interaction means in plain words
Avapritinib and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Rifampicin belongs to Anti Bacterial.
Why it happens
CYP3A4 induction by rifampicin accelerates avapritinib metabolism.
What to do
Avoid the combination and use a non-inducing alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Avapritinib
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Avapritinib with Rifampicin?
MediHelp rates the interaction as major. Avapritinib and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin strongly induces CYP3A4 and greatly reduces avapritinib exposure, likely causing loss of efficacy.
How serious is the interaction between Avapritinib and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative.
What other medicines interact with Avapritinib?
MediHelp also lists interactions of Avapritinib with, for example, Amobarbital, Apalutamide, Aprepitant. The full list is on the Avapritinib page.
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