Drug interactions
Avapritinib + Sertraline
Severity: Minor
Avapritinib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is metabolized mainly by CYP3A4, and moderate inhibitors can raise its exposure. Sertraline is only a weak inhibitor of CYP3A4, so the effect is likely small, but higher avapritinib levels would increase risks such as cognitive effects and bleeding.
What this interaction means in plain words
Avapritinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline may modestly reduce avapritinib clearance.
What to do
No dose change is usually needed. Monitor for cognitive changes, bleeding and edema during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Sertraline?
MediHelp rates the interaction as minor. Avapritinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib is metabolized mainly by CYP3A4, and moderate inhibitors can raise its exposure. Sertraline is only a weak inhibitor of CYP3A4, so the effect is likely small, but higher avapritinib levels would increase risks such as cognitive effects and bleeding.
How serious is the interaction between Avapritinib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for cognitive changes, bleeding and edema during treatment.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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