Drug interactions
Avapritinib + Ticagrelor
Severity: Moderate
Avapritinib and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is a CYP3A4 substrate, and ticagrelor is a weak CYP3A4 inhibitor, so avapritinib levels may increase modestly. Avapritinib also carries intracranial hemorrhage risk, and its combination with an antiplatelet may add to bleeding concerns.
What this interaction means in plain words
Avapritinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by ticagrelor, plus additive bleeding risk.
What to do
Monitor for avapritinib adverse effects, including cognitive changes and bleeding. Avoid the combination in patients with elevated hemorrhage risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Ticagrelor?
MediHelp rates the interaction as moderate. Avapritinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib is a CYP3A4 substrate, and ticagrelor is a weak CYP3A4 inhibitor, so avapritinib levels may increase modestly. Avapritinib also carries intracranial hemorrhage risk, and its combination with an antiplatelet may add to bleeding concerns.
How serious is the interaction between Avapritinib and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for avapritinib adverse effects, including cognitive changes and bleeding. Avoid the combination in patients with elevated hemorrhage risk.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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