Drug interactions
Avapritinib + Valproic acid
Severity: Minor
Avapritinib and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause CNS effects including sedation and cognitive impairment, so combined use may add to these. Valproate has little CYP3A4 inhibition, so a pharmacokinetic effect on avapritinib is unlikely to be significant.
What this interaction means in plain words
Avapritinib and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Valproic acid belongs to Central Nervous System.
Why it happens
Additive CNS effects; no established pharmacokinetic mechanism.
What to do
Monitor for sedation, confusion and memory problems, and reduce doses if cognitive effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Valproic acid?
MediHelp rates the interaction as minor. Avapritinib and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause CNS effects including sedation and cognitive impairment, so combined use may add to these. Valproate has little CYP3A4 inhibition, so a pharmacokinetic effect on avapritinib is unlikely to be significant.
How serious is the interaction between Avapritinib and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and memory problems, and reduce doses if cognitive effects emerge.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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