Drug interactions
Avapritinib + Warfarin
Severity: Major
Avapritinib and Warfarin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib is associated with intracranial and other hemorrhage and thrombocytopenia, which can add to the bleeding risk of warfarin. Patients on anticoagulants face a higher risk of serious bleeding.
What this interaction means in plain words
Avapritinib and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic bleeding risk from avapritinib-related thrombocytopenia and platelet effects with warfarin anticoagulation.
What to do
Monitor INR and platelet counts closely and watch for neurological or bleeding signs. Consider an alternative anticoagulant strategy and avoid use if platelets are low.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avapritinib and Warfarin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Avapritinib
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Avapritinib with Warfarin?
MediHelp rates the interaction as major. Avapritinib and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Avapritinib is associated with intracranial and other hemorrhage and thrombocytopenia, which can add to the bleeding risk of warfarin. Patients on anticoagulants face a higher risk of serious bleeding.
How serious is the interaction between Avapritinib and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR and platelet counts closely and watch for neurological or bleeding signs. Consider an alternative anticoagulant strategy and avoid use if platelets are low.
What other medicines interact with Avapritinib?
MediHelp also lists interactions of Avapritinib with, for example, Amobarbital, Apalutamide, Aprepitant. The full list is on the Avapritinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
