Drug interactions
Avapritinib + Zafirlukast
Severity: Minor
Avapritinib and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast has weak inhibitory activity on CYP3A4 and may raise avapritinib exposure modestly. Avapritinib has dose-related adverse effects including cognitive effects, intracranial hemorrhage and edema, so higher exposure could matter.
What this interaction means in plain words
Avapritinib and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Zafirlukast belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of avapritinib by zafirlukast.
What to do
No empiric dose change is needed; monitor for avapritinib adverse effects such as cognitive changes, edema and bleeding signs, and reduce the dose per labeling if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Zafirlukast?
MediHelp rates the interaction as minor. Avapritinib and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast has weak inhibitory activity on CYP3A4 and may raise avapritinib exposure modestly. Avapritinib has dose-related adverse effects including cognitive effects, intracranial hemorrhage and edema, so higher exposure could matter.
How serious is the interaction between Avapritinib and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor for avapritinib adverse effects such as cognitive changes, edema and bleeding signs, and reduce the dose per labeling if toxicity develops.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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