Drug interactions
Avapritinib + Ziprasidone
Severity: Moderate
Avapritinib and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause CNS effects such as somnolence and cognitive impairment, so combined use may worsen sedation and confusion. Avapritinib is also associated with intracranial bleeding and cognitive effects that can be hard to distinguish from drug sedation.
What this interaction means in plain words
Avapritinib and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; ziprasidone's CYP3A4 inhibition is weak and not clinically established.
What to do
Monitor for sedation and cognitive changes and report new neurological symptoms promptly. Reduce doses if sedation becomes problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Ziprasidone?
MediHelp rates the interaction as moderate. Avapritinib and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause CNS effects such as somnolence and cognitive impairment, so combined use may worsen sedation and confusion. Avapritinib is also associated with intracranial bleeding and cognitive effects that can be hard to distinguish from drug sedation.
How serious is the interaction between Avapritinib and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes and report new neurological symptoms promptly. Reduce doses if sedation becomes problematic.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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