Drug interactions
Axitinib + Erythromycin lactobionate
Severity: Moderate
Axitinib and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin is a moderate CYP3A4 inhibitor and may increase axitinib exposure. This can heighten hypertension, bleeding and liver toxicity.
What this interaction means in plain words
Axitinib and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Erythromycin inhibits CYP3A4, lowering axitinib clearance.
What to do
Consider a non-interacting antibiotic such as azithromycin; otherwise monitor blood pressure and reduce axitinib dose if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Axitinib with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Axitinib and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin is a moderate CYP3A4 inhibitor and may increase axitinib exposure. This can heighten hypertension, bleeding and liver toxicity.
How serious is the interaction between Axitinib and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-interacting antibiotic such as azithromycin; otherwise monitor blood pressure and reduce axitinib dose if toxicity emerges.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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