Drug interactions
Axitinib + Fedratinib
Severity: Moderate
Axitinib and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can raise axitinib plasma concentrations. Higher exposure may increase adverse effects such as hypertension, diarrhea, hepatotoxicity and bleeding.
What this interaction means in plain words
Axitinib and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing the metabolic clearance of axitinib.
What to do
Monitor blood pressure, liver tests and tolerability, and consider reducing the axitinib dose if adverse effects emerge. Prefer an alternative with less CYP3A4 inhibition when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Axitinib with Fedratinib?
MediHelp rates the interaction as moderate. Axitinib and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and can raise axitinib plasma concentrations. Higher exposure may increase adverse effects such as hypertension, diarrhea, hepatotoxicity and bleeding.
How serious is the interaction between Axitinib and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, liver tests and tolerability, and consider reducing the axitinib dose if adverse effects emerge. Prefer an alternative with less CYP3A4 inhibition when possible.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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