Drug interactions
Axitinib + Fluconazole
Severity: Moderate
Axitinib and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole, a moderate CYP3A4 inhibitor, can increase axitinib concentrations. Higher exposure may increase adverse effects such as hypertension, diarrhea and hepatic toxicity.
What this interaction means in plain words
Axitinib and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated axitinib metabolism.
What to do
Prefer an alternative with no CYP3A4 inhibition. If it must be used, monitor blood pressure and tolerability and reduce the axitinib dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Fluconazole?
MediHelp rates the interaction as moderate. Axitinib and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole, a moderate CYP3A4 inhibitor, can increase axitinib concentrations. Higher exposure may increase adverse effects such as hypertension, diarrhea and hepatic toxicity.
How serious is the interaction between Axitinib and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative with no CYP3A4 inhibition. If it must be used, monitor blood pressure and tolerability and reduce the axitinib dose as needed.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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