Drug interactions
Axitinib + Idelalisib
Severity: Major
Axitinib and Idelalisib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can substantially increase axitinib exposure. This raises the risk of axitinib toxicity such as severe hypertension, bleeding, and hepatic effects.
What this interaction means in plain words
Axitinib and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axitinib belongs to Oncology; Idelalisib belongs to Oncology.
Why it happens
Idelalisib's metabolite inhibits CYP3A4, reducing axitinib clearance.
What to do
Choose an alternative with little or no CYP3A inhibition where possible. If unavoidable, reduce the axitinib dose by about half and monitor blood pressure and adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Axitinib with Idelalisib?
MediHelp rates the interaction as major. Axitinib and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and can substantially increase axitinib exposure. This raises the risk of axitinib toxicity such as severe hypertension, bleeding, and hepatic effects.
How serious is the interaction between Axitinib and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an alternative with little or no CYP3A inhibition where possible. If unavoidable, reduce the axitinib dose by about half and monitor blood pressure and adverse effects.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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