Drug interactions
Axitinib + Stiripentol
Severity: Moderate
Axitinib and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so axitinib exposure may rise or fall unpredictably. This can cause either toxicity or reduced efficacy.
What this interaction means in plain words
Axitinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 activity by both inhibition and induction, altering axitinib metabolism.
What to do
Monitor axitinib tolerability and treatment response. Adjust the axitinib dose according to observed toxicity or loss of effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Axitinib with Stiripentol?
MediHelp rates the interaction as moderate. Axitinib and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so axitinib exposure may rise or fall unpredictably. This can cause either toxicity or reduced efficacy.
How serious is the interaction between Axitinib and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor axitinib tolerability and treatment response. Adjust the axitinib dose according to observed toxicity or loss of effect.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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