Drug interactions
Azathioprine + Rilonacept
Severity: Moderate
Azathioprine and Rilonacept: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks interleukin-1 signalling and, combined with azathioprine, may increase the risk of infections. Clinical data on the combination are limited.
What this interaction means in plain words
Azathioprine and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Rilonacept belongs to Miscellaneous.
Why it happens
Additive immunosuppression from IL-1 blockade and inhibition of lymphocyte proliferation.
What to do
Monitor for signs of infection and avoid starting rilonacept during active infection. Review the need for each immunosuppressant regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Azathioprine with Rilonacept?
MediHelp rates the interaction as moderate. Azathioprine and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilonacept blocks interleukin-1 signalling and, combined with azathioprine, may increase the risk of infections. Clinical data on the combination are limited.
How serious is the interaction between Azathioprine and Rilonacept?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and avoid starting rilonacept during active infection. Review the need for each immunosuppressant regularly.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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