Drug interactions
Azelastine + Dantrolene
Severity: Moderate
Azelastine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness and dizziness. Combined with azelastine, which can cause somnolence, sedation may be intensified and affect safe performance of tasks.
What this interaction means in plain words
Azelastine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive central nervous system depressant effects.
What to do
Advise the patient about additive drowsiness and to avoid driving until tolerance is established. Monitor for excessive sedation and adjust therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Dantrolene
Frequently asked questions
Can I take Azelastine with Dantrolene?
MediHelp rates the interaction as moderate. Azelastine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness and dizziness. Combined with azelastine, which can cause somnolence, sedation may be intensified and affect safe performance of tasks.
How serious is the interaction between Azelastine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient about additive drowsiness and to avoid driving until tolerance is established. Monitor for excessive sedation and adjust therapy if needed.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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