Drug interactions
Azelastine + Fedratinib
Severity: Minor
Azelastine and Fedratinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4, and azelastine is not a recognized strong dual CYP3A4/CYP2C19 inhibitor. A clinically meaningful rise in fedratinib exposure is not well established.
What this interaction means in plain words
Azelastine and Fedratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine belongs to Respiratory; Fedratinib belongs to Oncology.
Why it happens
Possible weak CYP inhibition by azelastine; the mechanism is not well established.
What to do
No routine adjustment is needed. Monitor for fedratinib toxicity such as gastrointestinal effects and anemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Azelastine with Fedratinib?
MediHelp rates the interaction as minor. Azelastine and Fedratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib is metabolized by CYP3A4, and azelastine is not a recognized strong dual CYP3A4/CYP2C19 inhibitor. A clinically meaningful rise in fedratinib exposure is not well established.
How serious is the interaction between Azelastine and Fedratinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for fedratinib toxicity such as gastrointestinal effects and anemia.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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