Drug interactions
Azelastine + Fenfluramine
Severity: Moderate
Azelastine and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine is sedating while fenfluramine can cause either somnolence or stimulation, so the net effect is unpredictable. Fenfluramine labeling also warns of additive CNS depression with other depressants.
What this interaction means in plain words
Azelastine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Fenfluramine belongs to Central Nervous System.
Why it happens
Opposing and additive CNS effects; the net pharmacodynamic result is not well established.
What to do
Monitor for excessive drowsiness or changes in alertness when starting azelastine. Counsel on driving and machinery use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Azelastine with Fenfluramine?
MediHelp rates the interaction as moderate. Azelastine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine is sedating while fenfluramine can cause either somnolence or stimulation, so the net effect is unpredictable. Fenfluramine labeling also warns of additive CNS depression with other depressants.
How serious is the interaction between Azelastine and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness or changes in alertness when starting azelastine. Counsel on driving and machinery use.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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