Drug interactions
Azelastine + Finerenone
Severity: Minor
Azelastine and Finerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is cleared mainly by CYP3A4, and azelastine is reported as a weak CYP3A4 inhibitor, so finerenone exposure may increase slightly. Higher finerenone exposure raises the risk of hyperkalemia and reduced kidney function. Intranasal azelastine has low systemic exposure, so the effect is likely small.
What this interaction means in plain words
Azelastine and Finerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine belongs to Respiratory; Finerenone belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated finerenone metabolism.
What to do
Monitor serum potassium and renal function when starting or changing either drug. Adjust finerenone dosing per labeling if potassium rises.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Azelastine with Finerenone?
MediHelp rates the interaction as minor. Azelastine and Finerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Finerenone is cleared mainly by CYP3A4, and azelastine is reported as a weak CYP3A4 inhibitor, so finerenone exposure may increase slightly. Higher finerenone exposure raises the risk of hyperkalemia and reduced kidney function. Intranasal azelastine has low systemic exposure, so the effect is likely small.
How serious is the interaction between Azelastine and Finerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when starting or changing either drug. Adjust finerenone dosing per labeling if potassium rises.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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