Drug interactions
Azelastine + Melatonin
Severity: Minor
Azelastine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both substances promote drowsiness, so combining them may increase daytime sedation or next-day impairment. The effect is usually mild.
What this interaction means in plain words
Azelastine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine belongs to Respiratory; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive sedative effects through H1-receptor blockade and melatonin receptor agonism.
What to do
No dose change is generally required. Advise taking melatonin at bedtime and avoiding driving if drowsy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Azelastine with Melatonin?
MediHelp rates the interaction as minor. Azelastine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both substances promote drowsiness, so combining them may increase daytime sedation or next-day impairment. The effect is usually mild.
How serious is the interaction between Azelastine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Advise taking melatonin at bedtime and avoiding driving if drowsy.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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