Drug interactions
Azelastine + Mirtazapine
Severity: Moderate
Azelastine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is strongly sedating through antihistamine activity, and azelastine can add to this. The combination may cause marked drowsiness and impaired psychomotor performance.
What this interaction means in plain words
Azelastine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from combined H1-receptor antagonism.
What to do
Monitor for excessive sedation, especially at night and in older adults. Counsel patients on driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Azelastine with Mirtazapine?
MediHelp rates the interaction as moderate. Azelastine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine is strongly sedating through antihistamine activity, and azelastine can add to this. The combination may cause marked drowsiness and impaired psychomotor performance.
How serious is the interaction between Azelastine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, especially at night and in older adults. Counsel patients on driving and alcohol avoidance.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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