Drug interactions
Azelastine + Oxycodone
Severity: Moderate
Azelastine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine may add to oxycodone-induced sedation and respiratory depression. Risk is higher with high opioid doses, older age, or other CNS depressants.
What this interaction means in plain words
Azelastine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from H1-antagonist sedation and mu-opioid agonism.
What to do
Monitor sedation and respiratory rate, particularly when starting or increasing doses. Prefer a non-sedating antihistamine when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Azelastine with Oxycodone?
MediHelp rates the interaction as moderate. Azelastine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine may add to oxycodone-induced sedation and respiratory depression. Risk is higher with high opioid doses, older age, or other CNS depressants.
How serious is the interaction between Azelastine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, particularly when starting or increasing doses. Prefer a non-sedating antihistamine when possible.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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