Drug interactions
Azelastine + Risperidone
Severity: Moderate
Azelastine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause somnolence, and with azelastine the sedative effect may be additive. This may impair alertness and increase fall risk, particularly in older patients.
What this interaction means in plain words
Azelastine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and antihistaminic and alpha-adrenergic blocking effects of risperidone.
What to do
Monitor for sedation and dizziness and advise caution when driving. Consider a non-sedating antihistamine if drowsiness is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Azelastine with Risperidone?
MediHelp rates the interaction as moderate. Azelastine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause somnolence, and with azelastine the sedative effect may be additive. This may impair alertness and increase fall risk, particularly in older patients.
How serious is the interaction between Azelastine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness and advise caution when driving. Consider a non-sedating antihistamine if drowsiness is problematic.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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