Drug interactions
Azelastine-fluticasone + Clobazam
Severity: Moderate
Azelastine-fluticasone and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine that causes sedation and can depress respiration, and azelastine adds sedative effects. Together they may increase drowsiness and psychomotor impairment.
What this interaction means in plain words
Azelastine-fluticasone and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and H1-receptor antagonism.
What to do
Counsel on sedation and avoidance of driving until the response is known. Monitor for excessive drowsiness, especially in older adults or with other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Azelastine-fluticasone with Clobazam?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine that causes sedation and can depress respiration, and azelastine adds sedative effects. Together they may increase drowsiness and psychomotor impairment.
How serious is the interaction between Azelastine-fluticasone and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoidance of driving until the response is known. Monitor for excessive drowsiness, especially in older adults or with other CNS depressants.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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