Drug interactions
Azelastine-fluticasone + Etomidate
Severity: Minor
Azelastine-fluticasone and Etomidate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is a hypnotic anesthetic, and the small amount of azelastine absorbed from the nose may add to its sedative effect. The clinical effect is likely small because nasal azelastine exposure is low, but it is not zero.
What this interaction means in plain words
Azelastine-fluticasone and Etomidate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Etomidate belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from the sedating antihistamine azelastine and the GABA-A agonist etomidate.
What to do
Tell the anesthesia team that the patient uses an azelastine nasal spray and titrate etomidate to effect. Monitor sedation depth and recovery as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Etomidate?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Etomidate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etomidate is a hypnotic anesthetic, and the small amount of azelastine absorbed from the nose may add to its sedative effect. The clinical effect is likely small because nasal azelastine exposure is low, but it is not zero.
How serious is the interaction between Azelastine-fluticasone and Etomidate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team that the patient uses an azelastine nasal spray and titrate etomidate to effect. Monitor sedation depth and recovery as usual.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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