Drug interactions
Azelastine-fluticasone + Flibanserin
Severity: Moderate
Azelastine-fluticasone and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin is a CYP3A4 substrate, and inhibitors raise its levels, increasing hypotension, syncope and CNS depression. Azelastine is at most a weak CYP3A4 inhibitor, and the relevant concern is mainly additive sedation. Fluticasone is a CYP3A4 substrate rather than an inhibitor.
What this interaction means in plain words
Azelastine-fluticasone and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Flibanserin belongs to Genitourinary.
Why it happens
Possible weak CYP3A4 inhibition and additive sedation from azelastine, increasing flibanserin exposure and effects.
What to do
Counsel on dizziness, drowsiness and syncope and avoid alcohol. Monitor for hypotension and sedation, especially if other CYP3A4 inhibitors are also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Flibanserin?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin is a CYP3A4 substrate, and inhibitors raise its levels, increasing hypotension, syncope and CNS depression. Azelastine is at most a weak CYP3A4 inhibitor, and the relevant concern is mainly additive sedation. Fluticasone is a CYP3A4 substrate rather than an inhibitor.
How serious is the interaction between Azelastine-fluticasone and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on dizziness, drowsiness and syncope and avoid alcohol. Monitor for hypotension and sedation, especially if other CYP3A4 inhibitors are also used.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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