Drug interactions
Azelastine-fluticasone + Fluphenazine
Severity: Moderate
Azelastine-fluticasone and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is a phenothiazine antipsychotic with sedative properties, and azelastine can add to drowsiness. This may impair alertness and psychomotor performance.
What this interaction means in plain words
Azelastine-fluticasone and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 blockade by azelastine and the antipsychotic.
What to do
Counsel about additive drowsiness and avoid driving until response is known. Reduce or stop azelastine if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Azelastine-fluticasone with Fluphenazine?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine is a phenothiazine antipsychotic with sedative properties, and azelastine can add to drowsiness. This may impair alertness and psychomotor performance.
How serious is the interaction between Azelastine-fluticasone and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about additive drowsiness and avoid driving until response is known. Reduce or stop azelastine if sedation is troublesome.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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