Drug interactions
Azelastine-fluticasone + Lomitapide
Severity: Minor
Azelastine-fluticasone and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate, and inhibitors raise its exposure, increasing the risk of liver injury and GI effects. Fluticasone and azelastine are not recognized as meaningful CYP3A4 inhibitors, so the clinical risk is low.
What this interaction means in plain words
Azelastine-fluticasone and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Lomitapide belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 interaction; no significant inhibition is established.
What to do
Continue standard lomitapide monitoring of liver enzymes. No change is needed for the nasal spray.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Lomitapide?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide is a sensitive CYP3A4 substrate, and inhibitors raise its exposure, increasing the risk of liver injury and GI effects. Fluticasone and azelastine are not recognized as meaningful CYP3A4 inhibitors, so the clinical risk is low.
How serious is the interaction between Azelastine-fluticasone and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue standard lomitapide monitoring of liver enzymes. No change is needed for the nasal spray.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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