Drug interactions
Azelastine-fluticasone + Lurasidone
Severity: Moderate
Azelastine-fluticasone and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine can produce somnolence even when given intranasally, and lurasidone commonly causes sedation. Together they may add to CNS depression, with greater drowsiness and reduced alertness.
What this interaction means in plain words
Azelastine-fluticasone and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of a sedating antihistamine and an atypical antipsychotic.
What to do
Warn the patient about additive drowsiness and caution against driving until the response is known. Reassess the need for azelastine if daytime sedation becomes troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Lurasidone?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine can produce somnolence even when given intranasally, and lurasidone commonly causes sedation. Together they may add to CNS depression, with greater drowsiness and reduced alertness.
How serious is the interaction between Azelastine-fluticasone and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about additive drowsiness and caution against driving until the response is known. Reassess the need for azelastine if daytime sedation becomes troublesome.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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