Drug interactions
Azelastine-fluticasone + Meperidine
Severity: Moderate
Azelastine-fluticasone and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meperidine is an opioid that causes sedation and respiratory depression, and azelastine can add to drowsiness. Combined use may increase CNS depression and impair alertness.
What this interaction means in plain words
Azelastine-fluticasone and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and antihistamine sedation.
What to do
Monitor sedation and respiratory status, especially at initiation or dose increases of meperidine. Advise against driving and alcohol, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Meperidine?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meperidine is an opioid that causes sedation and respiratory depression, and azelastine can add to drowsiness. Combined use may increase CNS depression and impair alertness.
How serious is the interaction between Azelastine-fluticasone and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, especially at initiation or dose increases of meperidine. Advise against driving and alcohol, and use the lowest effective doses.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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