Drug interactions
Azelastine-fluticasone + Midazolam
Severity: Moderate
Azelastine-fluticasone and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is a potent benzodiazepine sedative and azelastine can add to drowsiness. Combined use may increase sedation and impair psychomotor and respiratory function.
What this interaction means in plain words
Azelastine-fluticasone and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and histamine H1 blockade.
What to do
Monitor the level of sedation and respiration, especially in procedural settings, and titrate midazolam to effect. Counsel outpatients on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Midazolam?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam is a potent benzodiazepine sedative and azelastine can add to drowsiness. Combined use may increase sedation and impair psychomotor and respiratory function.
How serious is the interaction between Azelastine-fluticasone and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the level of sedation and respiration, especially in procedural settings, and titrate midazolam to effect. Counsel outpatients on avoiding driving and alcohol.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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