Drug interactions
Azelastine-fluticasone + Paliperidone
Severity: Moderate
Azelastine-fluticasone and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can cause somnolence and azelastine may also cause drowsiness. Together they may increase sedation and impair alertness.
What this interaction means in plain words
Azelastine-fluticasone and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Counsel the patient about additive drowsiness and avoiding driving until response is known. Consider fluticasone alone if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Azelastine-fluticasone with Paliperidone?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can cause somnolence and azelastine may also cause drowsiness. Together they may increase sedation and impair alertness.
How serious is the interaction between Azelastine-fluticasone and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and avoiding driving until response is known. Consider fluticasone alone if sedation is troublesome.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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