Drug interactions
Azelastine-fluticasone + Phentermine
Severity: Minor
Azelastine-fluticasone and Phentermine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a stimulant, which may counteract some azelastine-induced drowsiness, but the net effect varies between patients. No clinically significant interaction is well documented.
What this interaction means in plain words
Azelastine-fluticasone and Phentermine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Phentermine belongs to Central Nervous System.
Why it happens
Opposing CNS pharmacodynamic effects; no established pharmacokinetic mechanism.
What to do
No routine adjustment is needed. Advise the patient that alertness may still be impaired and to assess personal response before driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Phentermine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Phentermine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phentermine is a stimulant, which may counteract some azelastine-induced drowsiness, but the net effect varies between patients. No clinically significant interaction is well documented.
How serious is the interaction between Azelastine-fluticasone and Phentermine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Advise the patient that alertness may still be impaired and to assess personal response before driving.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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