Drug interactions
Azilsartan-chlorthalidone + Dalteparin
Severity: Moderate
Azilsartan-chlorthalidone and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins, including low molecular weight heparins, can suppress aldosterone secretion and cause hyperkalemia. Combined with an ARB, the risk is additive, particularly in renal impairment or diabetes, though the chlorthalidone component lowers potassium.
What this interaction means in plain words
Azilsartan-chlorthalidone and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone synthesis adds to angiotensin receptor blockade, reducing renal potassium excretion.
What to do
Monitor serum potassium, especially when dalteparin is used for more than a few days or in patients with renal impairment or diabetes. Treat hyperkalemia if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Dalteparin?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins, including low molecular weight heparins, can suppress aldosterone secretion and cause hyperkalemia. Combined with an ARB, the risk is additive, particularly in renal impairment or diabetes, though the chlorthalidone component lowers potassium.
How serious is the interaction between Azilsartan-chlorthalidone and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially when dalteparin is used for more than a few days or in patients with renal impairment or diabetes. Treat hyperkalemia if it develops.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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