Drug interactions
Azilsartan-chlorthalidone + Ephedrine
Severity: Moderate
Azilsartan-chlorthalidone and Ephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine can cause a small intracellular shift of potassium, and thiazide-like diuretics deplete potassium. Hypokalemia may be somewhat greater, and ephedrine's pressor action can also oppose the antihypertensive effect.
What this interaction means in plain words
Azilsartan-chlorthalidone and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Ephedrine belongs to Cardiovascular.
Why it happens
Beta-adrenergic stimulation drives potassium into cells, adding to diuretic-induced renal potassium loss; sympathomimetic vasoconstriction antagonizes blood pressure control.
What to do
Monitor blood pressure and serum potassium if ephedrine is used regularly. Avoid repeated use in patients with hypertension or arrhythmia risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Ephedrine?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ephedrine can cause a small intracellular shift of potassium, and thiazide-like diuretics deplete potassium. Hypokalemia may be somewhat greater, and ephedrine's pressor action can also oppose the antihypertensive effect.
How serious is the interaction between Azilsartan-chlorthalidone and Ephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium if ephedrine is used regularly. Avoid repeated use in patients with hypertension or arrhythmia risk.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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