Drug interactions
Azilsartan-chlorthalidone + Furosemide
Severity: Moderate
Azilsartan-chlorthalidone and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone and furosemide together produce potent sequential nephron blockade, causing marked diuresis. This can lead to hypokalemia, hyponatremia, hypomagnesemia, volume depletion and renal impairment.
What this interaction means in plain words
Azilsartan-chlorthalidone and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Additive diuretic action from loop and thiazide-like diuretics increases renal potassium, sodium and water loss.
What to do
Monitor electrolytes, creatinine, weight and blood pressure after starting or adjusting doses. Replace potassium and magnesium and lower diuretic doses if hypovolemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Furosemide?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone and furosemide together produce potent sequential nephron blockade, causing marked diuresis. This can lead to hypokalemia, hyponatremia, hypomagnesemia, volume depletion and renal impairment.
How serious is the interaction between Azilsartan-chlorthalidone and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, creatinine, weight and blood pressure after starting or adjusting doses. Replace potassium and magnesium and lower diuretic doses if hypovolemia occurs.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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