Drug interactions
Azilsartan-chlorthalidone + Gentamicin
Severity: Major
Azilsartan-chlorthalidone and Gentamicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin can cause renal tubular injury with potassium and magnesium wasting, and diuretics increase these losses. Volume depletion from chlorthalidone may also increase gentamicin nephrotoxicity and ototoxicity.
What this interaction means in plain words
Azilsartan-chlorthalidone and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive electrolyte wasting and volume depletion from the diuretic increase aminoglycoside tubular toxicity.
What to do
Monitor renal function, potassium, magnesium and gentamicin levels, and keep the patient well hydrated. Consider holding the diuretic and ARB during acute illness or high-dose aminoglycoside therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Gentamicin?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gentamicin can cause renal tubular injury with potassium and magnesium wasting, and diuretics increase these losses. Volume depletion from chlorthalidone may also increase gentamicin nephrotoxicity and ototoxicity.
How serious is the interaction between Azilsartan-chlorthalidone and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, potassium, magnesium and gentamicin levels, and keep the patient well hydrated. Consider holding the diuretic and ARB during acute illness or high-dose aminoglycoside therapy.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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