Drug interactions
Azilsartan-chlorthalidone + Labetalol
Severity: Minor
Azilsartan-chlorthalidone and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol and azilsartan-chlorthalidone are both antihypertensives, so combining them produces additive blood pressure lowering with potential for hypotension and dizziness. Beta blockers may also mask hypoglycemia in diabetic patients, and chlorthalidone may alter glucose and potassium.
What this interaction means in plain words
Azilsartan-chlorthalidone and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering through different mechanisms.
What to do
Monitor blood pressure and heart rate, adjusting doses as needed. Check electrolytes periodically and counsel diabetic patients about masked hypoglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Labetalol?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labetalol and azilsartan-chlorthalidone are both antihypertensives, so combining them produces additive blood pressure lowering with potential for hypotension and dizziness. Beta blockers may also mask hypoglycemia in diabetic patients, and chlorthalidone may alter glucose and potassium.
How serious is the interaction between Azilsartan-chlorthalidone and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, adjusting doses as needed. Check electrolytes periodically and counsel diabetic patients about masked hypoglycemia.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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