Drug interactions
Azilsartan-chlorthalidone + Mefenamic acid
Severity: Moderate
Azilsartan-chlorthalidone and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid can blunt the antihypertensive effect of azilsartan and chlorthalidone. Combined with an ARB and diuretic it raises the risk of acute kidney injury, particularly in elderly or volume-depleted patients.
What this interaction means in plain words
Azilsartan-chlorthalidone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and reduced renal perfusion with angiotensin blockade and diuresis.
What to do
Use the lowest dose for the shortest time and ensure hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Mefenamic acid?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid can blunt the antihypertensive effect of azilsartan and chlorthalidone. Combined with an ARB and diuretic it raises the risk of acute kidney injury, particularly in elderly or volume-depleted patients.
How serious is the interaction between Azilsartan-chlorthalidone and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest dose for the shortest time and ensure hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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