Drug interactions
Azilsartan-chlorthalidone + Succinylcholine
Severity: Moderate
Azilsartan-chlorthalidone and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can raise serum potassium, while diuretic-induced electrolyte disturbance can alter neuromuscular blockade response and arrhythmia risk. Azilsartan can increase potassium as well. The net effect on potassium during anesthesia is unpredictable.
What this interaction means in plain words
Azilsartan-chlorthalidone and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Opposing and additive effects on serum potassium: depolarization-induced potassium release versus diuretic potassium loss and ARB potassium retention.
What to do
Check electrolytes before anesthesia and correct abnormalities. Monitor potassium and ECG perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Succinylcholine
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Succinylcholine?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine can raise serum potassium, while diuretic-induced electrolyte disturbance can alter neuromuscular blockade response and arrhythmia risk. Azilsartan can increase potassium as well. The net effect on potassium during anesthesia is unpredictable.
How serious is the interaction between Azilsartan-chlorthalidone and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes before anesthesia and correct abnormalities. Monitor potassium and ECG perioperatively.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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