Drug reference
cisapride
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Gastrointestinal Tract (Prokinetic)
Mechanism of action
Promotes gastric emptying, increases lower esophageal sphincter tone and esophageal peristalsis, Increases gastric motility and cardiac rate possibly by releasing acetylcholine at the myenteric plexus; may act at the serotonin-4 receptor
Common side effects
- Headache
- Abdominal pain
- Diarrhea
Contraindications
- Hypersensitivity Serious cardiac arrhythmias (eg, ventricular fibrillation, torsades de pointes, and QT prolongation) reported in patients taking cisapride with other drugs that inhibit cytochrome CYP3A4 or have additive QT prolonging effect; some of these events have been fatal Patient histo…
Known interactions (8)
- cisapride + clarithromycin Contraindicated
- cisapride + escitalopram Contraindicated
- cisapride + mifepristone Contraindicated
- alfuzosin + cisapride Major
- aripiprazole + cisapride Major
- atomoxetine + cisapride Major
- cisapride + ipratropium-salbutamol Moderate
- cisapride + salbutamol Moderate
Related conditions
Frequently asked questions
What drug class is cisapride?
cisapride belongs to: Gastrointestinal Tract.
How does cisapride work?
Promotes gastric emptying, increases lower esophageal sphincter tone and esophageal peristalsis, Increases gastric motility and cardiac rate possibly by releasing acetylcholine at the myenteric plexus; may act at the serotonin-4 receptor
What are the common side effects of cisapride?
Headache, Abdominal pain, Diarrhea
Which drugs interact with cisapride?
clarithromycin, escitalopram, mifepristone, alfuzosin, aripiprazole, atomoxetine, ipratropium-salbutamol, salbutamol
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