Drug interactions
Azithromycin + Desflurane
Severity: Moderate
Azithromycin and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can prolong the QT interval, so perioperative combined use may add to arrhythmic risk, particularly with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Azithromycin and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Desflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Check ECG and correct electrolytes before surgery in patients on azithromycin. Monitor ECG during anesthesia and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Azithromycin with Desflurane?
MediHelp rates the interaction as moderate. Azithromycin and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can prolong the QT interval, so perioperative combined use may add to arrhythmic risk, particularly with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Azithromycin and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct electrolytes before surgery in patients on azithromycin. Monitor ECG during anesthesia and avoid adding other QT-prolonging drugs.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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