Drug interactions
Azithromycin + Dicloxacillin
Severity: Minor
Azithromycin and Dicloxacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin is bacteriostatic and may theoretically blunt the bactericidal activity of dicloxacillin. Clinical relevance is unproven, and the pair is commonly used together without evident problems.
What this interaction means in plain words
Azithromycin and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azithromycin belongs to Anti Bacterial; Dicloxacillin belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: reduced bacterial replication lessens the effect of cell-wall-active beta-lactams.
What to do
No routine change is needed; monitor clinical response in serious infections and avoid unneeded combination therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Dicloxacillin?
MediHelp rates the interaction as minor. Azithromycin and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azithromycin is bacteriostatic and may theoretically blunt the bactericidal activity of dicloxacillin. Clinical relevance is unproven, and the pair is commonly used together without evident problems.
How serious is the interaction between Azithromycin and Dicloxacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor clinical response in serious infections and avoid unneeded combination therapy.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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