Drug interactions
Azithromycin + Edoxaban
Severity: Moderate
Azithromycin and Edoxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin may inhibit P-glycoprotein and modestly raise edoxaban exposure, with a possible increase in bleeding risk. The effect is generally modest.
What this interaction means in plain words
Azithromycin and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Edoxaban belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition by azithromycin reduces edoxaban efflux and clearance.
What to do
Monitor for signs of bleeding; no routine edoxaban dose reduction is generally needed, but reassess in patients with renal impairment or low body weight.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Azithromycin with Edoxaban?
MediHelp rates the interaction as moderate. Azithromycin and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin may inhibit P-glycoprotein and modestly raise edoxaban exposure, with a possible increase in bleeding risk. The effect is generally modest.
How serious is the interaction between Azithromycin and Edoxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding; no routine edoxaban dose reduction is generally needed, but reassess in patients with renal impairment or low body weight.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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