Drug interactions
Azithromycin + Granisetron
Severity: Moderate
Azithromycin and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin has been associated with QT prolongation and torsades de pointes, and granisetron may add to this effect. The risk is mainly in patients with other predisposing factors.
What this interaction means in plain words
Azithromycin and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation.
What to do
Correct potassium and magnesium and review other QT-prolonging drugs. Obtain an ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Granisetron?
MediHelp rates the interaction as moderate. Azithromycin and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin has been associated with QT prolongation and torsades de pointes, and granisetron may add to this effect. The risk is mainly in patients with other predisposing factors.
How serious is the interaction between Azithromycin and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and review other QT-prolonging drugs. Obtain an ECG in patients with cardiac risk factors.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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